Diagnostic performance of a new two-dimensional shear wave elastography expression using siemens ultrasound system combined with ACR TI-RADS for classification of benign and malignant thyroid nodules: A prospective multi-center study

ObjectiveThe present study aimed to evaluate the efficacy of a new two-dimensional shear wave elastography (2D-SWE) method using Siemens ultrasound system and its combination with American College Radiology Thyroid Imaging Reporting Data System (ACR TI-RADS) for differential diagnosis benign malignant thyroid nodules.MethodsConventional images 2D-SWE (E-whole-mean E-stiffest-mean) were prospectively analyzed in 593 nodules from 543 patients. Nodules divided into diameter (D) ≤10 mm D > 10 groups graded ACR TI-RADS. The receiver operating characteristic curve was plotted pathological findings as gold standard. Diagnostic performance compared among 2D-SWE, TI-RADS, their combination.ResultsThe area under (AUC) E-whole-mean higher than that E-stiffest-mean (0.858 vs. 0.790, P < 0.001), which indicated it better parameter differentiating an optimal cut-off point 11.36 kPa. In all-sizes group, AUC TI-RADS 0.808, 0.001). resulted (0.929 0.858 sensitivity (87.0% 80.3% 85.2%), specificity (85.1% 74.0% 73.6%), accuracy (86.3% 78.1% 81.1%), positive predictive value (91.5% 85.1% 85.6%), negative (78.0% 67.0% 72.9%) or alone. superior alone both ≤ (P 0.001).ConclusionAs parameter, had diagnostic power enhanced when identifying nodules. improved alone, providing reliable clinical